The role of Sildenafil and Bacillus clausii for the prevention of methotrexate induced mucositis: a preclinical study

Objective: Methotrexate (MTX) is a commonly used chemotherapeutic agent in clinical oncology practice and treatment of autoimmune diseases. The major side effect during mucositis. Recently published studies reported that this may be due to direct intestinal epithelial injury disturbance microbiota. In study, we aimed characterize the histological changes caused by MTX investigate effects safety Sildenafil probiotic Bacillus clausii on mucositis rat model. Materials Methods: rats were divided 4 groups; Group1(n=8) received + B. clausii, Group 2 (n=8) only MTX, Group3 (n=7) was served as control (received no treatment). Results: rate villus atrophy, villous fusion erosion group found statistically significantly lower than group. Conclusion: study demonstrated repairing mucosa after MTX-treatment. better understanding probiotics mucosal protection lead new therapeutic approaches chemotherapy-induced